The plague persists in nature by infecting wild rodents-including mice, rats, squirrels, chipmunks, groundhogs, and prairie dogs-and their fleas. Tufts Now: What is the plague, and who is at risk?įelicia Nutter: The plague is a serious infectious disease caused by the bacteria Yersinia pestis. Tufts Now spoke with Nutter about the ancient disease, who’s still at risk, and how to protect yourself and your pets. The plague has never left-it has been here all along, even in the United States-and it can usually be treated with antibiotics, so long as it is properly diagnosed. “When you hear about the plague, you may think of the Black Death-the epidemic estimated to have killed 50 million people or more during the 1300s,” said Cummings School assistant professor Felicia Nutter, V93.īut there’s no need to panic, said Nutter, a board-certified wildlife veterinarian and epidemiologist. With pandemic anxiety at a worldwide high because of COVID-19, the last thing anyone wants to see in the news is word of another plague-especially the plague, which has recently been reported in people in China and Mongolia and, closer to home, in a squirrel in Colorado.
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The values of D* and f were higher in tumour progression patients than that in pseudoprogression patients ( p < 0.05). The values of ADC, D, DDC, and α values were lower in tumour progression patients than that in pseudoprogression patients ( p < 0.05). Interclass correlation coefficient (ICC) was used to evaluate the consistency of measurements. Receiver operating characteristic curves (ROC) analysis was used to investigate the diagnostic performance of different DWI parameters. The apparent diffusion coefficient (ADC) from a monoexponential model, the true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) from a biexponential model, and the distributed diffusion coefficient (DDC) and intravoxel heterogeneity index (α) from a stretched-exponential model were compared between tumour progression and pseudoprogression groups. All patients underwent conventional and multi-b diffusion-weighted MRI. Methodsįorty patients with pathologically confirmed glioblastoma exhibiting enhancing lesions after completion of chemoradiation therapy were enrolled in the study, which were then classified as tumour progression and pseudoprogression. To investigate the diagnostic performance of parameters derived from monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging models in differentiating tumour progression from pseudoprogression in glioblastoma patients. 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